Project data
Funding Entity: Italian Ministry of University and Research (MUR)
Call: PRN 2017
Coordinator: Consiglio Nazionale delle Ricerche (CNR)
UNISI Principal Investigator: Prof. Elisa Frullanti
Department: Department of Medical Biotechnologies (DBM)
Start date: 29 August 2019
End date: 29 August 2023
Description
The aim of the project is to apply the CRISPR/cas9 gene editing technology for the treatment of neurodevelopment disorders caused by the “cellular interference” mechanism due to mutations in PCDH19 gene, for which there are currently no treatments. To this aim, this project plans to act on the molecular cause of the disease by correcting cellular interference through the use of the innovative CRISPR/Cas9 “gene editing” technology, both in-vitro and in-vivo.
This project has received funding from Ministry of University and Research (MUR) – PRIN 2017