A contact force sensor device comprising a gas-inflatable balloon and a processing unit, for use within robotic endoscopic instruments.
The invention enables to perform video assisted odontology and allows for accurate visual examination with less operational difficulties.
The invention relates to high affinity compounds, able to bind the transient receptor potential cation channel, subfamily Vanilloid type 1 (TRPV1), and to inhibit the Fatty Acid Amide Hydrolase (FAAH). These compounds find application in pain therapy and as novel radiotracers for Positron Emission Tomography (PET) imaging.
The invention refers to in vivo stable branched peptides, conjugated to functional units for specific targeting of cancer cells, either for diagnosis or therapy of tumours.
The invention covers a bacteriophage, i.e. a virus specific against bacteria, able to selectively eliminate microrganisms causing infections. In particular, the target of the bacteriophage is a specific clone of antibiotic resistant bacteria widely diffused at worldwide level and able to give serious infections that are difficult to be treated by using conventional therapeutic approaches.
The present invention relates to:
- Peptides binding to human thymidylate synthase for the treatment of cancer. The peptides of 4-8 amino acids bind to each subunit of the protein dimer interface, stabilizing the inactive form.
- Pharmaceutical composition of these compounds as active agents, and user for the treatment of cancer and to reverse or/and be active in cancer drug resistance.
Hyaluronic Acid (HI) is a widespread physiological polymer suffering from in vivo degradation. Infiltration or ocular administration of HI are therefore common strategies to reduce osteoarticular inflammation, ocular dryness and dermal quality degradation. Nonetheless the benefits are limited because the treatments are symptomatic and do not address the problem of HI enzymatic degradation. The modified HI we propose preserves the physical and chemical properties of native HI (lubricant, injectable, a-toxic, hydrating) but is more stable in vivo at enzymatic degradation and is able to regulate the uncontrolled enzymes’ inflammatory activity.
System for distributed control of smartphone devices distributed in a physical space to reproduce visual and video patterns in public events.
The invention relates to imidazo[1,2-alpha]pyrazin-3(7H)-one derivatives comprising an hetero-atom and their use as chemiluminescent and/or bioluminescent reagents.
A method that utilizes 3D scans of the patient’s face to 3D print customized facemasks for the treatment of Class III malocclusions. The customized facemasks also feature pressure and temperature sensors, which are linked to both, a game app for mobile devices, in order to promote patient’s compliance and an app for monitoring the therapy by the orthodontist.
The pyrazole [4,3-b] pyridine-6-carboxy amide derivatives in question show direct antibacterial activity against Gram-positive bacteria such as Bacillus subtilis, Enterococcus faecalis, Streptococcus pyogenes and Staphylococcus aureus, as well as a synergistic antibacterial activity with polymyxins, such as polymyxin E1, against Gram-negative bacteria such as Acinetobacter baumanii.
Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.
The invention relates to imidazo[1,2-alpha]pyrazin-3(7H)-one derivatives comprising an hetero-atom and their use as chemiluminescent and/or bioluminescent reagents.
The invention is a task-custom haptic finger exoskeleton device providing both kinesthetic stimuli along the finger and three-dimensional cutaneous force on the fingertip surface, either generated independently to each other or at the same time. The device can be used in a rehabilitative scenario, gaming, and remote control of manipulators.
Molecules of natural origin potentially capable of modulating the Hedgehog signaling pathway were selected in silico. For SMO antagonists, a ligand-based pharmacophoric approach was followed that focused on the chemical structure of some clinical trial SMO antagonists. Structure-based methods based on the crystallographic structure of the Gli1 / DNA complex were used for Gli1 inhibitors.
The sixth finger is a wearable robotic device to assist or augment the human grasping capabilities. The device can be tied to different parts of the human body, such as the forearm, wrist or ankle, and when unused fits onto the body, wrapping the limb or body part on which it is worn (like a bracelet, anklet, belt).
A method for the detection and quantification of specific immunoglobulins E (IgE) for an allergen of interest in a patient’s serum sample, and a device for achieving this method.
A method and related devices designed to manage the interaction between collaborative robots and human operators through the generation of an awareness signal from the robot to the operator during their duties. It allows the robot to detect and anticipate the operator’s movements and ensures the operator that the collaborative robot has correctly interpreted the operator’s actions.
The invention relates to triketones compounds for their use in the prevention and treatment of a disease characterized by accumulation of homogentisic acid (HGA) or succinyl acetoacetate and succinylacetone. The invention also relates to compositions comprising such compounds.
The invention is a wearable haptic system to guide the gait rhythm of a person through vibrating stimuli. The system can suggest the speed of the step to avoid collision with a moving object or to synchronize the step with that of another person, as well can signal the need to change direction to reach a particular destination.
The system comprises an element contacting bone processes close to a user’s ear, that generates vibrations at adjustable frequency, intensity and wavelength to reduce tinnitus in the user. The user relays instructions as to which frequency, intensity and/or wavelength perception of tinnitus is significantly reduced.
The invention deals with the medical methodologies and device that allow biomedical analysis and consists of a new method of quantitative analysis of oxidative stress in biological samples and the device to carry out this method.
The invention concerns a peptide having anti-tumour activity, designated TS/PP, and its derivatives. In particular, the invention concerns a peptide with anti-tumour preventive and therapeutic activity, also in combination with other known anti-tumour compounds such as, 5’-fluorouracil.
Process for the automatic generation of parallel calculation code with a high level of abstraction which can be performed on electronic processors with multi-core, many-core or heterogeneous hybrid architectures.
Compounds of formula I, their use as medicaments, their combination with a further antiviral agent and related pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an envelope virus.
A method and related device for the automatic handling of flexible items, such as clothes, bags and the like. A mechanical manipulator, coupled to an independent magnetic manipulator, is guided via magnetic interactions at specific points of the flexible object to be manipulated, where a ferromagnetic source is placed.
The system consists of two viral particles, encoding a guide RNA recognizing the region of the mutated DNA, and a donor sequence as template to correct the mutation. The system is applicable in personalized gene replacement therapy of monogenic diseases such as Pompe disease, Rett syndrome, Alport syndrome and Parkinson disease.
Apparatus and manufacturing method for volumetric stimulation of cells, comprising an air inflatable end-effector coupled to an actuation system. The apparatus is compatible with most laboratory glass- or plasticware, and is therefore intended for mechanobiology research, medium and high throughput biological and pharmaceutical screening.